For comparison, 29 healthy elderly control subjects (HC) were enrolled in the study. Data were recorded from 272 patients from the cohort of the German consortium for frontotemporal lobar degeneration (FTLDc): 111 with behavioral variant frontotemporal dementia (bvFTD), 98 with primary progressive aphasia (PPA), 30 with progressive supranuclear palsy Richardson's syndrome, 17 with corticobasal syndrome (CBS) and 16 with amyotrophic lateral sclerosis with frontotemporal dementia (ALS/FTD). The applause sign was elicited with the three clap test (TCT), with a higher score indicating poorer performance. The aim of this study was to determine the prevalence of the applause sign and correlate its presence with neuropsychological and MRI volumetry findings in frontotemporal lobar degeneration and related conditions. Recent research, however, has provided evidence for the occurrence of the applause sign in various conditions. The applause sign, i.e., the inability to execute the same amount of claps as performed by the examiner, was originally reported as a sign specific for progressive supranuclear palsy (PSP).
17 German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.16 AMEOS Klinikum Heiligenhafen, Heiligenhafen, Germany.15 Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.14 Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany.13 German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.12 Department of Neurology, Rostock University Medical Center, Rostock, Germany.11 Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany.10 Max Planck Institute of Human Cognitive and Brain Sciences (MPG), Leipzig, Germany.9 German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.8 Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.7 Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.6 Department of Neurology, Saarland University, Homburg, Germany.5 Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany.4 Swiss Epilepsy Clinic, Klinik Lengg, Zurich, Switzerland.3 Department of Neurology, University of Ulm, Ulm, Germany.2 Neurologische Klinik und Poliklinik, Ludwig Maximilians Universität München, Munich, Germany. 1 Neurologische Klinik und Poliklinik, Ludwig Maximilians Universität München, Munich, Germany.
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